عنوان البحث(Papers / Research Title)
The Association of Serum Androgen Levels with Preeclampsia
الناشر \ المحرر \ الكاتب (Author / Editor / Publisher)
نادية مضر سلمان مرزة
Citation Information
نادية,مضر,سلمان,مرزة ,The Association of Serum Androgen Levels with Preeclampsia , Time 5/30/2011 9:55:05 PM : كلية الطب
وصف الابستركت (Abstract)
serumandrogens in preeclampsia
الوصف الكامل (Full Abstract)
The Association of Serum Androgen Levels with Preeclampsia
Dr.Nadia Mudher Al-Hilli, FIBMS (Ob/Gyn)
Dr.Haydar Hashim Al-Shalah, FIBMS (Clinical Path)
Babylon University/ College of Medicine/ Department of Obstetrics & Gynaecology
Babylon University/ College of Medicine/ Department of Biochemistry
Abstract:
Background: Preeclampsia is a major cause of morbidity and mortality during pregnancy. Several independent investigators have demonstrated the association of androgens with hypertension.
Objective:To determine whether maternal serum levels of testosterone & dehydroepiandrosterone sulphate DHEA-S, are higher in patients with preeclampsia than in matched normotensive control subjects.
Method: Case control study included 29 subjects in the 3rd trimester of pregnancy with documented preeclampsia (including 10 cases of mild and19 cases of severe preeclampsia) and 20 healthy normotensive women in the third trimester of pregnancy used as control group & for comparative purpose another 13 patients with gestational hypertension were also included in our study. All cases had singleton pregnancies.
Cases of polycystic ovary syndrome (PCOS), diabetes, chronic hypertension and chronic systemic diseases such as lupus and patients using steroid drugs were excluded.Serum levels of total testosterone were measured using testosterone enzyme immunoassay test kit, Biocheck (USA), while dehydroepiandrosterone sulfate (DHEA-S) was measured using DHEA-S enzyme immunoassay test kit, DRG (USA, Germany).
Results: Student t-test was used to analyze the difference in androgen levels between the different groups. Serum total testosterone level was significantly higher in patients with severe pre-eclampsia compared to control group (0.41ng/mL versus 0.31ng/mL, P value 0.005), while no significant difference was found between cases of mild & severe pre-eclampsia. Again no significant difference was found when comparing patients with mild pre-eclampsia with control group & cases of gestational hypertension with control group.Serum level of dehydroepiandrosterone sulfate (DHEA-S) was significantly higher in patients with severe pre-eclampsia compared to patients with mild pre-eclampsia (1.03 µg/mL versus 0.32 µg/mL; P value 0.005) & when compared with control group (1.03 µg/mL versus 0.59 µg/mL; P value 0.02), while the level was not significantly higher when comparing cases of mild pre-eclampsia with control group & cases of gestational hypertension with control group.
Conclusion: Levels of total testosterone & dehydroepiandrosterone sulfate (DHEA-S) were significantly higher in women with severe preeclampsia than in normotensive women. The levels of these androgens were higher in women severe pre-eclampsia when compared to women with mild pre-eclampsia & those with gestational hypertension. This difference may indicate a role for androgens in the pathogenesis of preeclampsia and stimulates research in the potential role of anti-androgens in the management of preeclampsia.
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