ABSTRACT
This study was done in the college of medicine /Babylon university from March 2014 to April 2014. A total of 20
adult male albino rats randomly subdivided in to 4 groups containing 5 rats in each group as the following:
Group A: In this group, all rats administered 0.5 ml normal saline 0.9% through the catheter via the urethra into
the urinary bladder.
Group B: In this group, all rats received 0.5 ml of (bacteria 109 /ml) through the catheter via the urethra into the
urinary bladder.
Group C: All rats in this group administered 0.5 ml of (bacteria 109 /ml) through the catheter via the urethra into
the urinary bladder and treated with curcumin in dose (100 mg\kg\day, p.o).
Group D: all rats in this group administered 0.5 ml of (bacteria 109 /ml) through the catheter via the urethra into
the urinary bladder and treated with Cranberry (7mg/kg/day, orall).
Some virulence gene of P.mirabilis such as mrpA and ureC are investigates and it is found that this two genes
(mrpA and ureC) is present in all isolates (group B)
The effect of curcumin and cranberry on urease were investigated, genetically there are no effect of curcumin and
cranberry on the gene of urease while phenotypically it was stat the high concentration of it could cause inhibition to
urease production
Also ,the effect of curcumin and cranberry on adhesion factor was also studied it was found genetically there are
no effect of curcumin and cranberry on the gene of adherencegene while phenotypically that found failed to formation
agglutination in the presence of D-mannose that treated with curcumin and cranberry.
These data show that curcumin and cranberry can provide protective effect against nephrolithiasis this protective
effect of curcumin and cranberry may be related to the antioxidant status on the kidney.