Calcium phosphate is widely used as bone scaffold
because of its degradation and biocompatible properties. The
scaffold must provide high surface area for cellular adhesion
from biological surrounding, and suitable mechanical properties
for the substitution of damaged bones. Also, the scaffold
must be biocompatible, degradable, and the resorption controlled
to match those of natural tissues. There are numerous
procedures designed for the scaffold that depend on innovation
and experiment. The scaffold was prepared by sacrificial
method of mixing calcium phosphate powder with polymeric
powder polyethylene glycol (PEG). Then, pressing in the cylindrical
mold uniaxially, and porous structure of hydroxyapatite
and ?-tricalcium phosphate (HA/?-TCP) was obtained
after sintering. Genetic algorithm optimization was used to
optimize the compressive strength; the ratio of brushite and
porosity were the parameters of problem. By maximizing the
objective function genetic optimization showed that the best
compressive strength was (54.67MPa) at 25 wt% ratio of
brushite and 40% volume fraction of porosity and experimental
value (53.3MPa).The slight difference between these
values, perhaps attributable to uncontrolled conditions such
as moisture, presence of agglomerate, and the morphology
of porosity and other factors, could have led to this difference