Abstract
Background: Knee osteoarthritis (KOA) is considered a major cause of physical disability, and because its
prevalence increases with age, the coexistence with other chronic diseases is common making further
impact on health and lifestyle.
Objective: To find out the correlation and frequencies of comorbidities( obesity, hypertension, diabetes
mellitus(DM), dyslipidemia and metabolic syndrome) in patients with KOA ,to compare the result with
that of individual without KOA, and to study how could these components impact pain in patients with
KOA.
Methods : sixty five patients (40 females and 25 males) with symptomatic KOA were enrolled in the study
in period between March 2010 to May 2011 at rehabilitation and rheumatologic clinic of Merjan teaching
hospital . The OA was diagnosed according to American college of rheumatology criteria(ACR) and
according to Kellegren-Lawrence radiographic grade for OA , Grade 2+ (definite osteophyte) was used as
definition of KOA. Similar number of individuals without KOA nearly matched for age and gender were
selected as a control group. Full medical history and physical examination were recorded. Body mass
index (BMI) ,waist circumference(WC), fasting blood sugar, total cholesterol, triglyceride, high density
lipoprotein( HDL) cholesterol, blood pressure were estimated for patients. and control groups.
Pain was measured in patients with KOA using visual analogue scale , (VAS).
Results: The frequency of co morbidities among patients with symptomatic KOA was as following:
obesity (55.38%), dyslipidemia (49.23%) DM (18.4%) hypertension (64.6%) and metabolic
syndrome(50.76% ).which were higher than control group.
Comparing these components patients with metabolic syndrome had higher pain impact measured by VAS
than patients without metabolic syndrome..
Conclusions: Metabolic risk factors or components of metabolic syndrome were associated closely with
KOA. Which need investigation, detection and early treatment when dealing with KOA.
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