:The first to describe Epidemic Keratoconjunctivitis was James Sanders is an English physician. EKC, commonly known as pink eye, shipyard conjunctivitis, Sanders, disease and Sanders-Hogan syndrome. The form of EKC occurred during World War II was Shipyard disease or shipyard eye. EKC is one of the most common causes of acute conjunctivitis, with distinctive clinical features such as sudden onset of acute follicular conjunctivitis, watery discharge, hyperemia, chemosis, and ipsilateral Infection of human keratocytes with adenoviruses auricular lymphadenopathy. -preIn results in expression of chemokines before the beginning of viral gene expression. terms of innate immunity, some epithelial cells release anti-microbial defens in peptides infection. Recently, cytokines are play physiologic adenovirusesthat defense against roles in maintaining the ocular surface, alteration on cytokines level in tears may be The present study aimed to Objective: ocular surface.reflected by extraordinary in the detect of HAdVs in conjunctival sw