Association of Human Leukocyte Antigen-(HLA-B 27) Gene
Polymorphism with Vitiligo Disease
Mona N. Al-Terehi1, Zainab Abbas Al-Talebi1, Abbas Hussein Mugheer2, Ali H. Al-Saadi1, Fathia ATeeq Rajab3
1College of Science, 2College of Basic Education, University of Babylon, Iraq; 3Omar Al-Mukhtar
University, El-Gubba
ABSTRACT
Vitiligo have been recorded in different ages in population it is appeared by interaction between different
factors causes de-pigmentation in skin, the present study conducted to estimate HLA 27 gene polymorphism
in vitiligo patients using single specific primer-polymerase chain reaction (PCR-SSP), DNA was extracted
from whole blood for patients and control, then amplification was implemented, the results of demographic
show that the means of age were 33.093 and 32.809 for patients and control, disease was recorded in female
than male 79.54%, 18.18%, about 36.36% of patient had family history and56.81% of them, their parents had
family related. High percentage of patients had dispersive sites of de-pigment sites 54.54% while 40.90% of
them in hands and legs. The genotyping results show that there was no association between HLA B27 and
vitiligo disease, HLA – was 95.83% in patients while it was 85.71% in control in non-significant differences
This study concluded that there was no association between HLA B 27 and vitiligi disease in Iraqi population.