ABSTRACT
Background and Objective: Ischemic heart disease (IHD) is one of the commonest reasons for morbidity and
mortality universally. The principal etiopathology of IHD is coronary atherosclerosis. Serum uric acid (SUA), is
found to be associated with IHD in several meta-analyses, independent of other risk factors. Hepatic acute phase
reactant C-reactive protein (CRP) has a recognized contribution to vascular inflammation. Up till now, no
sufficient data is yet available to show the correlation of both UA and HSCRP to each other and with IHD in our
country. Therefore, this study was conducted to evaluate the causal-effect of SUA, and CRP and their diagnostic
correlation in admitted patients with IHD.
Material and Methods: This was a case-control study, including 260 participants (160 patients with IHD and 100
healthy control). Blood samples were drawn from all participants within 24 hours of admission. Biochemical
analyses included: fasting/random glucose, total lipid profile, creatinine, estimated GFR, SUA and HSCRP tests
were completed for all participants were measured. According to their SUA levels participants divided into
normourecemic and hyperuricemic groups (?6.5 and > 6.5mg/dl sequentially). Likewise, serum levels of HSCRP
into (< 3.5 mg/L and >3.5mg/L). A comparison of biochemical findings between IHD and controls were
performed. SPSS-25 (IBM-USA) was applied for the statistical examination. Estimations of ORs, as well as 95%
confidence intervals, where stated. P-values < 0.05 were allocated as significant. ROC-curve examination was
analyzed to determine accuracy, specificity, sensitivity for both SUA and HSCRP mutually.
Results: The overall prevalence of hyperuricemia was 29% among all participants and was equivalent in both
sexes, while HSCRP tertiles were higher significantly in males (p-0.003). Biochemical assays of SUA, HSCRP and
lipid profile being higher in IHD patients significantly. There was a trend to have a higher risk of IHD occurrence in
those with higher SUA and HSCRP mutually but not reach a statistical significance. After ROC-curve was
analyzed, significant higher predictability of HSCRP vis SUA for diagnosing subjects with IHD as an outcome was
reached. There was no strong association between the SUA and HSCRP. Still, the levels of HSCRP may have an
association with increased SUA levels, but not reach statistical significance.
Conclusions: Serum levels of both UA and HSCRP increased significantly in patients with IHD. Higher levels of
HSCRP could have an association with higher levels of SUA. Further studies are mandatory to complete our
understanding pathophysiology of IHD and AS process.