عنوان البحث(Papers / Research Title)
Outbreak of Epidemic Keratoconjunctivitis Caused By Human Adenoviruses in Central Iraq
الناشر \ المحرر \ الكاتب (Author / Editor / Publisher)
نيران كاظم فرهود الربيعي
Citation Information
نيران,كاظم,فرهود,الربيعي ,Outbreak of Epidemic Keratoconjunctivitis Caused By Human Adenoviruses in Central Iraq , Time 29/03/2021 17:00:25 : كلية طب حمورابي
وصف الابستركت (Abstract)
The present study aims to detect human adenoviruses in conjunctival swabs of patients with keratoconjunctivitis
الوصف الكامل (Full Abstract)
Background: Epidemic keratoconjunctivitis (EKC) is caused by human adenoviruses belong to the genus Mastadenovirus of the family Adenoviridae. Human adenoviruses comprise more than 60 different serotypes/types classified into seven groups (A–G). EKC is a hyper acute and highly contagious infection of the eye caused by HAdV-D particularly, types 8, 19 and 37. More recently, HAdV-D53, D54, and D56 also have been associated with EKC. Adenovirus infections are implicated in most keratoconjunctivitis cases and it is more common in adults than children.
Objective: The present study aims to detect human adenoviruses in conjunctival swabs of patients with keratoconjunctivitis and to clarify the significance of HAdVs in patients living in Babylon Governorate.
Results: The results of this study showed that human adenoviruses was identified in 84 of the 93 conjunctival specimens using the nestedPCR assay, but not present in 9 specimens. EKC most frequently occurred between 21- 40 years age group. EKC was predominantly in male (76.2%) from female (23.8%) and it is more common in adults (91.7%), but rarely occurred in children (8.3%).The most prevalent signs and symptoms were red eye, conjunctivitis, pain, itching tearing decreased visual acuity and photophobia were presented (100%) in all HAdVs cases, following by foreign body sensation (84.5%), chemosis (76.2%), subepithelial infiltrates (75%) bilateral (73.8%) conjunctival membrane (72.6%) pseudomembranes (71.4%) and conjunctival hemorrhage (38%). It is also noteworthy that in some cases the pharyngitis (22.6%) and rhinorrhea (21.4%) as concomitant finding. Outbreak of epidemic keratoconjunctivitis caused by HAdVs was reaching its peak in November (23.8%).
Conclusion: The results of our study were concluded that nested-PCR technique was found to be suitable and it was simplified for application in the clinical laboratory. All age groups are susceptible for infection with HAdVs but the age groups (21-40) years old have the peak incidence of epidemic keratoconjunctivitis and the rate of outbreak EKC in male was higher than female. In addition, the highest outbreak of adenovirus has been noticed in the November month.
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