The Relationship Between Serum Testosterone Level And Antioxidants Status In Pre-Eclampsia
 
   Tariq H.AL-Khyatt   Moaed  E. AL-Gazally  Sinaa B. Mohammed
College of Medicine, University of Babylon, Hilla, Iraq.
 
 

Abstract
 
   Pre-eclampsia  is a disease characterized by elevation  of blood pressure and proteinuria after the 20th  week of  gestation.

Serum levels of testosterone,  malondialdehyde,  reduced glutathione, catalase, total protein, albumin, globulin, zinc, and copper were determined in sera of 50 pre- eclamptic pregnants and 50 apparently healthy pregnants who served as control.

The results revealed :-A significant increment in the concentration of testosterone (p<0.01), malondialdehyde (p<0.01) and globulin (p<0.05) in sera of pre-eclamptics compared to normotensive pregnants concomitant with a significant reduction in the serum level of reduced glutathione (p<0.05), catalase (p<0.05), total protein (p<0.05) and albumin(p<0.05) in sera of pre-eclamptics compared to normotensive pregnants while there is no significant difference in the level of zinc and copper (p>0.05) in sera of pre-eclamptics compared to normotensive pregnants. Finally a significant  positive correlation  between  testosterone   level   and malondialdehyde (p<0.01) in sera of both pre-eclamptics and normotensive pregnants, a significant negative correlation between testosterone level and catalase activity (p<0.01) in both pre-eclamptics and normotensive pregnants, and significant negative correlation between testosterone, and reduced glutathione (p<0.05) in pre-eclamptics; (p<0.01) in normotensive pregnants.