عنوان البحث(Papers / Research Title)
Prognostic Significance of Troponin T and Creatine Kinase-MB
الناشر \ المحرر \ الكاتب (Author / Editor / Publisher)
علاء حسين عباس الحلي
Citation Information
علاء,حسين,عباس,الحلي ,Prognostic Significance of Troponin T and Creatine Kinase-MB , Time 6/22/2011 6:55:43 AM : كلية الطب
وصف الابستركت (Abstract)
Prognostic Significance of Troponin T and Creatine Kinase-MB
الوصف الكامل (Full Abstract)
Prognostic Significance of Troponin T and Creatine Kinase-MBActivity in Sera of Acute Ischaemic Stroke Patients
Alaa Hussain Abbase Haider Dheya Kazim Al-KhefajiCollege of Medicine, University of Babylon, Hilla, Iraq.
Abstract
Background and purpose: Elevation of sera cardiac troponin T (cTnT) concentration and creatine kinase-MB (CK-MB) activity and electrocardiographic changes can occur after ischaemic stroke. The aim of this study was to identify the relation ships between elevated cardiac biochemical markers with ECG changes , stroke severity and in-hospital mortality and to look for source of CK-MB. Patients and method: From 1 June 2009 to 1 October 2009 this study recruited 70 patients (46 males ,24 females ) who were admitted to Merjan teaching hospital due to acute ischaemic stroke which confirmed by neurologist , blood samples were taken for cTnT and CK-MB measurement and ECG was done. The stroke severity as assessed by Scandinavian stroke scale, and in hospital death were compared between the two groups of the cTnT and CK-MB. Hypertension and diabetes were separately compared between two groups of cTnT and CK-MB.
Results: Sera cTnT concentration and CK-MB activity were elevated in 22.9% , 35.7% of cases respectively . ECG changes occured in 45.7% . In contrast to elevated CK-MB activity, elevated cTnT associated with greater stroke severity and in hospital deaths .ECG changes were more in patients withelevated cTnT than in patients with elevated CK-MB. CK-MB was not elevated in most patients with elevated cTnT, the non parallel increase of CK-MB with cTnT signify the non cardiac source of CKMB. Hypertension and diabetes mellitus were more common in the elevated cTnT patients than normal cTnT group.
Conclusion: Elevated sera cTnT in patients with acute ischaemic stroke were associated with severe neurological deficits and in hospital deaths. The elevated CK-MB was mostly non-cardiac source and not correlated with stroke severity and in hospital death. The elevated cTnT along with ECG changes , hypertension and diabetes mellitus signify underlying asymptomatic coronary artery disease.
تحميل الملف المرفق Download Attached File
|
|