This research included the impact of phenol extract of Lepidium sativum seeds in sperm parameters of adult male
rabbit. The In Vivo study included the estimation of the Medium Effect Dose (MED50) for phenol extraction by
using Dose-Response Curve. The mean of MED50 was 36.1 mg /kg body weight (b.w.) of phenol. The results
showed a significant increase (P in testicular sperm concentration, epididymus sperm concentration and
in the sperm count per gm of the testis, sperm motility percent, grade activity, sperm viability percent,and
abnormal sperm morphology percent of epididymis caudal at MED50 of phenol. The results reveal that
supplement with low doses of phenol could be enhance rabbit fertility.