Abstract
Hyperhomocysteinaemia has emerged as a novel risk factor for cardiovascular disease . In non-insulin dependent diabetes mellitus (NIDDM ), cardiovascular disease (CVD) is one of the major macrovascular complication . The present study was conducted to examine the effect of homocysteine concentration and glycemic control in type 2 diabetic patients . Sixty type 2 diabetic patient were studied .These patients were categorized to good glycemic control (30) , poor glycemic control (30) diabetic patients and (30 ) healthy volunteers were enrolled in to the study as controls . The degree of glycemic control in diabetic patients was evaluated by HbA1c concentration.
Significant increases were obtained in HbA1c concentration and total serum of homocysteine levels in patients as whole compared with corresponding control values .Although HbA1c concentration was significantly higher in good glycemic control compared to poor glycemic control but there was no significant difference in homocysteine levels in patients with good and poor glycemic control .
These results suggest that there is an elevation of serum homocysteine level in type 2 diabetic patients , however there is no association between homocysteine levels and glycemic control in patients with type 2 diabetes .