This paper has used the optimization parameters to obtain the maximum compressive strength of scaffold. The porosity and ratio of brushite phase were taken as problem parameters. However, the regression equation was obtained using design of experiment method, also the regression equation which represent the objective function was optimized by using genetic algorithm method. HA/?-TCP scaffold has prepared by using sacrificial method via use of the particle of polymer (PEG) as poregen. The porosity that obtained in the range (40-54%). On the other hand, the best compressive strength by the use of genetic algorithm was 54.67 Mpa, it is approximately on a close with of the experimental value 53.3 Mpa.