Abstract
Background: Acute leukemia is a proliferation of immature bone
marrow-derived cells (blasts) that may also involve peripheral blood or
solid organs. Erythropoietin, is a glycoprotein hormone that controls
erythropoiesis, or red blood cell production also has other range of
actions including vasoconstriction-dependent hypertension, stimulating
angiogenesis,and inducing proliferation of smooth muscle fibers.
Objective: to evaluate serum level of erythropoietin in patients with
acute leukemia.
Research design and methods: In this case-control study, serum
level of erythropoietin measured in 22 patients with Acute leukemia and
22 apparently healthy subjects using ELISA. Statistical analysis was
performed using SPSS 17.0 .
Results: There was a significant increment in level of erythropoietin in
patients with acute leukemia compared to apparently healthy subjects (P
< 0.001) independently to other parameters.
Iraqi National Journal of Chemistry
Journal homepage:
http://iqnjc.com/Default.aspx
Iraqi National Journal of Chemistry 2015; 15(2)
141
Conclusion: Erythropoietin concentrations may predict adverse
outcomes, and their measurement may facilitate risk estimation in
leukaemic patients.
Keywords: Acute leukemia, erythropoietin.
Abbreviations: EPO: erythropoietin, AML: acute myloid leukaemia
ALL: acute lymphocytic leukaemia ,KD: kilodalton, ELISA: enzyme
linked immunosorbent assay, SD: standard deviation.