Abstract:
Aims of study : The present study was undertaken to assess the renoprotective effect of
irbesartan on gentamicin induced nephrotoxicity in male rats.
Materials and methods: Fifteen male adult Sprague-Dawely rats were enrolled in this
study, rats were separated randomly into 3 groups, five rats in each group, the first group
maintained on normal standard chow diet, served as control group. The second group
received gentamicin 100 mg/kg/day, i.p for 4 weeks. The third group received gentamicin
100mg/kg/day i.p concomitantly with irbesartan 25 mg/kg/day p.o for 4 weeks.
Results: Gentamicin treatment increased serum urea, creatinine and tissue
malondialdehyde (MDA) significantly. Irbesartan treatment decreased serum urea, creatinine
and tissue MDA significantly.
Conclusion: Gentamicin induced nenephrotoxicity can be prevented by coadministration
with irbesartan.