The aim of this study was to investigate the predominant type of MCV in children and adolescents who consulted Murjan Educational hospital in Babylon/ Iraq and to detect CD95L concentration during the infection. A total of thirty MCV patients and twenty two healthy persons were selected for viral, histological and immunological tests by using histological, PCR and ELISA techniques. The results were revealed that : 99% of patients of MC proved positive PCR, MCV-1 is the predominant type including high infection rate in children with age group (<10). The concentration of CD95L was highest in patients sera compared with control group . There was significant Mean Differences of FSAL Concentration by MCV’s location especially at the hand and face. The results showed that mean SD of CD95l at patients whom have pervious MCV less than one year of infection have higher percentage of infection with increased of CD95l level, while CD95l concentration at patients with MCV lesion more than one year.