ABSTRACT
Introduction and Aim: The Hydatidiform mole is one of a group of diseases referred to as gestational trophoblastic
disease (GTD), and the commonest type of GTD. Classification of a hydatidiform mole into complete
and partial depends on histopathological and cytogenetic features. An H mole is considered to be a
premalignant condition, with approximately 15% of complete and 1% of partial moles progress to a malignant
gestational trophoblastic neoplasia (GTN). The objectives of the study were to assess nutritional status as a
possible cause of Hydatidiform mole. In addition, to investigate the changes in the homocysteine, Retinol
binding protein, Pre albumin, and albumin in the first-trimester pregnant women compared to non-pregnant.
Materials and Methods: This was a case-control study which included (75) subjects,(25) of them were patients
group, the other (25) were pregnant women in the first trimester (first control group), and the remainder
(25) were nonpregnant women were (second control group).The sera obtained from the fasting blood of subjects
were used to measure the level of homocysteine, Retinol binding protein, pre-albumin, and albumin).
Results: The results of the present study showed that The mean age of patients group was (27.44 ± 5.36)
years, ranging from 18-39 years and the peak incidence of PHM between 22-29 years. The majority (76%) of
a patient with hydatidiform mole came from the rural area. Accident finding at ultrasonography was the commonest
way of presentation (44%) followed by vaginal bleeding (40%) while (16%) hyperemesis gravidram.
The Pre albumin level was significantly lower in the Pregnant women with mole compared with healthy pregnant
women control group (P < 0.001), but the homocysteine level was not significantly different (P = 0.146).
The levels of homocysteine and albumin were found significantly different between first-trimester pregnant
women and non-pregnant (P < 0.001).
Conclusion: The highest incidence of PHM was found in the age group between 22-29 years, belonging to the
rural city. PHM was more common in nulliparous and low parous patients having 1-2 children. The accidental
finding of ultrasonography was the commonest way of presentation followed by vaginal bleeding. This is the
first report to suggest that there may be an association between pre-albumin and PHM. But it is also suggesting
that there may be no association between homocysteine and PHM.