ABSTRACT : The aim of the study was to determine the protective role of Foeniculumvulgare against the renal toxicity induced
by Cisplatin in male rabbits. 30 adult male rabbits were randomly divided to three equal groups (10 animals / group). The first
group (G1) administered 1 ml / kg normal saline and was considered as a control group. The second group (G2) was injected
with Cisplatin (Cis) solution intra-peritoneally (IP), once at a dose of 6mg/kg body weight for induction of renal failure . while
the third group (G3) was injected inerperitonially with 6 mg/kg of Cis + oral dosage of 60 mg / kg of Foeniculum vulgare
extract for three months. Blood samples were withdrawn after starvation of the animals at night after the end of the experiment
to study the following parameters: measurement the concentration of Creatinin (Cr), Uric acid, Urea (Ur), Sodium (Na+) and
Potassium (K+) concentration, as well as measurement of oxidative stress indicators, including the measurement of the reduced
glutathion (GSH), Malondialdehyde (MDA), peroxy nitrite (ONOO_) and tumor necrosis Factor( TNF-a) concentration. The
results of the experiment showed that the injection of Cis resulted in a significant increase (P <0.05) in the concentration of Cr,
uric acid, Ur, K+, MDA, ONOO_ and TNF- Comparative to control group and significant decrease (P <0. 05) in Na+ and GSH
comparative with control group. The group that treatment with the alcohol extract of the fennel plant showed significant
decrease (P <0.05) in the concentration of Cr, uric acid, Ur, K+, MDA and TNF-a comparative with G2 and no significant
differences in Na+ and GSH concentration comparative with control group.