Betamethasone is one of the most used public drugs around the world due to its ability to
treatment into many different diseases. It is used as an example, for skin diseases, allergic
reactions, rheumatic disorders, Crohn s disease, and also for leukaemia[1]. In some drugs
manufacturers, Betamethasone can be used to generate another drug, such as Clobetasol[2]. In
general, Betamethasone has been listed according to the World Health Organization(WHO)
model as an essential medicine for an anti-inflammatory and anti-pruritic drug[3].
In some countries, Betamethasone has different knowing names like Diprolene, Diprosone,
Celestamine, Proctor (in Pakistan) and Betamethasone sodium phosphate is known as Bentelan
in Italy [4]. The initial clinical trial results by the United Kingdom have been welcomed through
World Health Organization (WHO). It shows dexamethasone, a corticosteroid, can be lifesaving
for patients who are critically ill with COVID-19. The treatment was shown to reduce mortality
by about one third for patients on ventilators and for patients requiring only oxygen, mortality
was cut by about one fifth [5].
Molecular modelling calculations methods that are implemented into packaged programs such as the
Gaussian program, Spartan program, Hyperchem programs and other scientific world programs can
be uses for structural properties investigation to estimate the relation of drug structure and their
biological activities toward different inflexion diseases [6]. Based on Density Functional Theory
(DFT) which includes inter electronic interactions through functionally in many-electron and manyatom molecular systems. Becke-3-parameter-Lee–Yang–Parr (B3LYP) is used in optimised structure
electronic density investigation to chemical compounds due to higher accuracy of calculated results