عنوان البحث(Papers / Research Title)
Some Aspects In The Physiological Changes
الناشر \ المحرر \ الكاتب (Author / Editor / Publisher)
اسيل كامل شاكر العلي
Citation Information
اسيل,كامل,شاكر,العلي ,Some Aspects In The Physiological Changes , Time 6/13/2011 9:42:37 PM : كلية الصيدلة
وصف الابستركت (Abstract)
Some Aspects In The Physiological Changes In Patients With Renal Failure
الوصف الكامل (Full Abstract)
Some Aspects In The Physiological Changes In Patients With Renal Failure
Background:
Chronic renal failure (CRF) is a pathological syndrome developed due to a progressive destruction of renal structures by chronic nephropathies.
It is characterized by gradually increasing renal functions impairment. CRF can result from a number of conditions that cause permanent loss of nephrons, including chronic pyelonephritis, diabetic and non diabetic glomerulonephritis, hypertensive nephrosclerosis, , obstructive uropathies ,polycystic kidneys , drugs and toxins .
Regardless of the cause, chronic renal failure results in the loss of renal cells with a progressive deterioration of glomerular filtration, tubular reabsorptive capacity, and endocrine functions of the kidneys.
Objective:
This study is aimed to estimate variations in hematological and biochemical parameters in patients suffering from CRF on continuous hemodialysis aiming to prevent and treat these disorders .
Method:
The patients were recruited from the artificial kidney unite at Marjan teaching hospital in Babylon city.
They were suffering from chronic renal failure. Sixty three patients and sixty three healthy controls were enrolled in this study. Patients blood samples were used for the estimation of a number of biochemical and hematological parameters . The results of these patients were compared with that of the controls .
Results:
The study reveals that there were significant increases in the concentrations of the following parameters in male and female patients with CRF relative to the controls . These parameters include blood urea ,createnine ,uric acid ,SGOT, SGPT, ALK.Ph ,total bilirubine ,direct bilirubine, triglyceride ,HDL, serum Ph+, and serum K+ concentrations.
There were a significant decreases in the concentrations of the following parameters in male and female patients with CRF relative to the controls. These parameters include total serum protein, serum albumin, serum globulin, LDL, vLDL, serum cu+ ,and serum Zn+.
There were no significant differences in the concentrations of the following parameters in male and female patients with CRF relative to the controls. These parameters include blood sugar, indirect bilirubine ,cholesterol , serum Na+, serum Ca+.
Conclusion:
Our study supports the hypothesis that CRF is a critical disease that results in multi-systemic disorders. Therefore, patients who are at risk of CRF should be identified and treated.
Any delay in the diagnosis and treatment; failure to recognize the symptoms and seriousness of CRF remain a matter of a major concern in our country. Creatinine clearance as well as the estimation of GFR should be performed routinely in all patients at risk.
The renal disorders should be taken seriously and dealt with through a programmed health services at well equipped specialized clinics, and by a careful investigation. Furthermore, poor communication among staff in different specialties also adds to the difficulties of counseling the patients.
The incidence of anemia and hypertension in this study was very high therefore; a good attention should be directed to study these problems and creates solutions for them.
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